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NVIDIA DGX Spark vs AMD Instinct MI250X 128GB for local LLMs

91 reports on the NVIDIA DGX Spark and 0 on the AMD Instinct MI250X 128GB

Which is faster for local LLMs?

Nobody has reported the same model at the same quant on both cards yet, so there's no measured head-to-head. Memory bandwidth, which caps how fast a card can write, is 12.0x higher on the AMD Instinct MI250X 128GB (273 GB/s on the NVIDIA DGX Spark, 3,277 on the AMD Instinct MI250X 128GB). The estimates below compare them on the models people run most.

NVIDIA DGX Spark
Memory
128GB unified
Memory bandwidth
273 GB/s
FP16 compute
125 TFLOPS
Reports
91
AMD Instinct MI250X 128GB
Memory
128GB
Memory bandwidth
3,277 GB/s
FP16 compute
383 TFLOPS
Reports
0

Estimated by the calculator

The quant the calculator recommends for each card and its estimated speed at a 32,768-token context with 32 GB of system RAM, from memory bandwidth and the model's shape.

ModelNVIDIA DGX SparkAMD Instinct MI250X 128GB
Qwen3.8 27B4.0 t/sFP1633.4 t/sFP16
Qwen3.8 125B · 6B active14.4 t/sQ6_K119.8 t/sQ6_K
Qwen3.6 35B · 3B active14.5 t/sFP16120.2 t/sFP16
DeepSeek V4 Flash 284B · 13B active38.3 t/sQ2_K318.2 t/sQ2_K
Qwen3.6 27B4.0 t/sFP1633.4 t/sFP16
Gemma 4 26B · 4B active10.8 t/sFP1690.1 t/sFP16

Change the context, RAM or model in the calculator: NVIDIA DGX Spark · AMD Instinct MI250X 128GB

Every report on each card, with its source: NVIDIA DGX Spark · AMD Instinct MI250X 128GB

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