Instinct MI250X 128GB vs RTX 4090

For running local LLMs · 3 reports across 2 models

Side A

Instinct MI250X 128GB

Vendor: amd
VRAM: 128GB
Memory: Discrete

Side B

Vendor: nvidia
VRAM: 24GB
Memory: Discrete

Tokens per second by model

Model	Instinct MI250X 128GB	RTX 4090
Gemma 4up to 31B	—	149.6n=2
Qwen3.6up to 35B	—	25.0n=1

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